{"id":111105,"date":"2022-08-29T19:32:16","date_gmt":"2022-08-30T02:32:16","guid":{"rendered":"https:\/\/www.pandasilk.com\/what-is-silk-fibroin-scaffold\/"},"modified":"2025-01-12T14:29:24","modified_gmt":"2025-01-12T22:29:24","slug":"what-is-silk-fibroin-scaffold","status":"publish","type":"post","link":"https:\/\/www.pandasilk.com\/vi\/what-is-silk-fibroin-scaffold\/","title":{"rendered":"V\u1eadt li\u1ec7u n\u1ec1n t\u1ea3ng t\u01a1 t\u1eb1m fibroin: c\u1ea5u tr\u00fac v\u00e0 \u1ee9ng d\u1ee5ng"},"content":{"rendered":"<p>T\u01a1 t\u1eb1m l\u00e0 m\u1ed9t lo\u1ea1i protein t\u1ef1 nhi\u00ean c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb s\u00e2u t\u1eb1m, \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn v\u1edbi \u0111\u1ed9 m\u1ec1m m\u1ea1i, \u0111\u1ed9 b\u1ec1n v\u00e0 t\u00ednh sinh h\u1ecdc cao.  T\u1eeb l\u00e2u, t\u01a1 t\u1eb1m \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong d\u1ec7t may, nh\u01b0ng g\u1ea7n \u0111\u00e2y, n\u00f3 \u0111\u00e3 thu h\u00fat s\u1ef1 ch\u00fa \u00fd \u0111\u00e1ng k\u1ec3 trong l\u0129nh v\u1ef1c c\u00f4ng ngh\u1ec7 sinh h\u1ecdc v\u00e0 y sinh h\u1ecdc, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong vi\u1ec7c t\u1ea1o ra c\u00e1c lo\u1ea1i gi\u00e1 th\u1ec3 (scaffold) cho k\u1ef9 thu\u1eadt m\u00f4. Gi\u00e1 th\u1ec3 t\u01a1 t\u1eb1m fibroin, hay c\u00f2n g\u1ecdi l\u00e0 khung t\u01a1 t\u1eb1m, l\u00e0 m\u1ed9t trong nh\u1eefng \u1ee9ng d\u1ee5ng n\u1ed5i b\u1eadt nh\u1ea5t c\u1ee7a lo\u1ea1i v\u1eadt li\u1ec7u n\u00e0y.<\/p>\n<h3>1. C\u1ea5u tr\u00fac v\u00e0 t\u00ednh ch\u1ea5t c\u1ee7a gi\u00e1 th\u1ec3 t\u01a1 t\u1eb1m fibroin<\/h3>\n<p>Gi\u00e1 th\u1ec3 t\u01a1 t\u1eb1m fibroin \u0111\u01b0\u1ee3c t\u1ea1o ra t\u1eeb protein fibroin, th\u00e0nh ph\u1ea7n ch\u00ednh c\u1ee7a s\u1ee3i t\u01a1 t\u1eb1m.  Fibroin c\u00f3 c\u1ea5u tr\u00fac protein d\u1ea1ng s\u1ee3i, v\u1edbi c\u00e1c chu\u1ed7i polypeptide s\u1eafp x\u1ebfp song song v\u1edbi nhau, t\u1ea1o n\u00ean m\u1ed9t m\u1ea1ng l\u01b0\u1edbi b\u1ec1n ch\u1eafc.  C\u1ea5u tr\u00fac n\u00e0y mang l\u1ea1i cho fibroin t\u00ednh ch\u1ea5t c\u01a1 h\u1ecdc tuy\u1ec7t v\u1eddi, bao g\u1ed3m \u0111\u1ed9 b\u1ec1n k\u00e9o cao, \u0111\u1ed9 \u0111\u00e0n h\u1ed3i t\u1ed1t v\u00e0 kh\u1ea3 n\u0103ng ch\u1ecbu l\u1ef1c t\u1ed1t.  H\u01a1n n\u1eefa, fibroin c\u00f3 t\u00ednh sinh h\u1ecdc t\u01b0\u01a1ng th\u00edch cao, ngh\u0129a l\u00e0 n\u00f3 kh\u00f4ng g\u00e2y ph\u1ea3n \u1ee9ng mi\u1ec5n d\u1ecbch m\u1ea1nh m\u1ebd trong c\u01a1 th\u1ec3 v\u00e0 c\u00f3 th\u1ec3 ph\u00e2n h\u1ee7y sinh h\u1ecdc theo th\u1eddi gian.  T\u00ednh ch\u1ea5t n\u00e0y r\u1ea5t quan tr\u1ecdng trong \u1ee9ng d\u1ee5ng y sinh h\u1ecdc, gi\u00fap gi\u1ea3m thi\u1ec3u nguy c\u01a1 ph\u1ea3n \u1ee9ng ph\u1ee5 v\u00e0 cho ph\u00e9p m\u00f4 m\u1edbi ph\u00e1t tri\u1ec3n m\u1ed9t c\u00e1ch t\u1ef1 nhi\u00ean.<\/p>\n<h3>2. Ph\u01b0\u01a1ng ph\u00e1p ch\u1ebf t\u1ea1o gi\u00e1 th\u1ec3 t\u01a1 t\u1eb1m fibroin<\/h3>\n<p>C\u00f3 nhi\u1ec1u ph\u01b0\u01a1ng ph\u00e1p kh\u00e1c nhau \u0111\u1ec3 ch\u1ebf t\u1ea1o gi\u00e1 th\u1ec3 t\u01a1 t\u1eb1m fibroin, m\u1ed7i ph\u01b0\u01a1ng ph\u00e1p \u0111\u1ec1u c\u00f3 \u01b0u \u0111i\u1ec3m v\u00e0 nh\u01b0\u1ee3c \u0111i\u1ec3m ri\u00eang.  M\u1ed9t s\u1ed1 ph\u01b0\u01a1ng ph\u00e1p ph\u1ed5 bi\u1ebfn bao g\u1ed3m:<\/p>\n<ul>\n<li><strong>Ph\u01b0\u01a1ng ph\u00e1p h\u00f2a tan v\u00e0 \u0111\u00f4ng t\u1ee5:<\/strong>  T\u01a1 t\u1eb1m \u0111\u01b0\u1ee3c h\u00f2a tan trong dung m\u00f4i th\u00edch h\u1ee3p (nh\u01b0 dung d\u1ecbch LiBr ho\u1eb7c CaCl2), sau \u0111\u00f3 \u0111\u01b0\u1ee3c \u0111\u00f4ng t\u1ee5 trong dung d\u1ecbch kh\u00e1c \u0111\u1ec3 t\u1ea1o th\u00e0nh gel ho\u1eb7c m\u00e0ng fibroin. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y cho ph\u00e9p \u0111i\u1ec1u khi\u1ec3n \u0111\u1ed9 d\u00e0y v\u00e0 h\u00ecnh d\u1ea1ng c\u1ee7a gi\u00e1 th\u1ec3.<\/li>\n<li><strong>Ph\u01b0\u01a1ng ph\u00e1p k\u00e9o s\u1ee3i:<\/strong>  Dung d\u1ecbch fibroin \u0111\u01b0\u1ee3c k\u00e9o s\u1ee3i th\u00e0nh c\u00e1c s\u1ee3i nh\u1ecf, sau \u0111\u00f3 \u0111\u01b0\u1ee3c d\u1ec7t ho\u1eb7c \u0111an th\u00e0nh c\u00e1c c\u1ea5u tr\u00fac ba chi\u1ec1u.  Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y t\u1ea1o ra c\u00e1c gi\u00e1 th\u1ec3 c\u00f3 \u0111\u1ed9 x\u1ed1p cao, thu\u1eadn l\u1ee3i cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a t\u1ebf b\u00e0o.<\/li>\n<li><strong>Ph\u01b0\u01a1ng ph\u00e1p in 3D:<\/strong> C\u00f4ng ngh\u1ec7 in 3D cho ph\u00e9p t\u1ea1o ra c\u00e1c gi\u00e1 th\u1ec3 fibroin c\u00f3 h\u00ecnh d\u1ea1ng v\u00e0 c\u1ea5u tr\u00fac ph\u1ee9c t\u1ea1p, \u0111\u00e1p \u1ee9ng nhu c\u1ea7u thi\u1ebft k\u1ebf \u0111a d\u1ea1ng trong k\u1ef9 thu\u1eadt m\u00f4.  \u0110\u00e2y l\u00e0 m\u1ed9t h\u01b0\u1edbng nghi\u00ean c\u1ee9u \u0111ang ph\u00e1t tri\u1ec3n m\u1ea1nh m\u1ebd.<\/li>\n<\/ul>\n<table class=\"table table-striped table-bordered\">\n<thead>\n<tr>\n<th>Ph\u01b0\u01a1ng ph\u00e1p<\/th>\n<th>\u01afu \u0111i\u1ec3m<\/th>\n<th>Nh\u01b0\u1ee3c \u0111i\u1ec3m<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>H\u00f2a tan v\u00e0 \u0111\u00f4ng t\u1ee5<\/td>\n<td>\u0110\u01a1n gi\u1ea3n, d\u1ec5 th\u1ef1c hi\u1ec7n, ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c \u0111\u1ed9 d\u00e0y<\/td>\n<td>\u0110\u1ed9 x\u1ed1p th\u1ea5p<\/td>\n<\/tr>\n<tr>\n<td>K\u00e9o s\u1ee3i<\/td>\n<td>\u0110\u1ed9 x\u1ed1p cao, thu\u1eadn l\u1ee3i cho s\u1ef1 ph\u00e1t tri\u1ec3n t\u1ebf b\u00e0o<\/td>\n<td>Kh\u00f3 ki\u1ec3m so\u00e1t h\u00ecnh d\u1ea1ng<\/td>\n<\/tr>\n<tr>\n<td>In 3D<\/td>\n<td>T\u1ea1o h\u00ecnh ph\u1ee9c t\u1ea1p, ch\u00ednh x\u00e1c<\/td>\n<td>Thi\u1ebft b\u1ecb \u0111\u1eaft ti\u1ec1n, k\u1ef9 thu\u1eadt ph\u1ee9c t\u1ea1p<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>3. \u1ee8ng d\u1ee5ng c\u1ee7a gi\u00e1 th\u1ec3 t\u01a1 t\u1eb1m fibroin trong y sinh h\u1ecdc<\/h3>\n<p>Gi\u00e1 th\u1ec3 t\u01a1 t\u1eb1m fibroin c\u00f3 ti\u1ec1m n\u0103ng \u1ee9ng d\u1ee5ng r\u1ed9ng r\u00e3i trong y sinh h\u1ecdc, bao g\u1ed3m:<\/p>\n<ul>\n<li><strong>K\u1ef9 thu\u1eadt m\u00f4:<\/strong>  Gi\u00e1 th\u1ec3 fibroin \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m khung \u0111\u1ee1 cho s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00e1c lo\u1ea1i m\u00f4 kh\u00e1c nhau, nh\u01b0 m\u00f4 x\u01b0\u01a1ng, m\u00f4 s\u1ee5n, m\u00f4 da, v\u00e0 m\u00f4 th\u1ea7n kinh.  T\u00ednh sinh h\u1ecdc t\u01b0\u01a1ng th\u00edch cao v\u00e0 kh\u1ea3 n\u0103ng ph\u00e2n h\u1ee7y sinh h\u1ecdc c\u1ee7a fibroin gi\u00fap cho qu\u00e1 tr\u00ecnh t\u00e1i t\u1ea1o m\u00f4 di\u1ec5n ra hi\u1ec7u qu\u1ea3.<\/li>\n<li><strong>Ph\u1ee5c h\u1ed3i v\u1ebft th\u01b0\u01a1ng:<\/strong>  Gi\u00e1 th\u1ec3 fibroin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 l\u00e0m v\u1ebft th\u01b0\u01a1ng nhanh l\u00e0nh h\u01a1n, gi\u1ea3m s\u1eb9o v\u00e0 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh t\u00e1i t\u1ea1o m\u00f4.<\/li>\n<li><strong>Thu\u1ed1c v\u1eadn chuy\u1ec3n:<\/strong>  Fibroin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng l\u00e0m ch\u1ea5t mang thu\u1ed1c, gi\u00fap gi\u1ea3i ph\u00f3ng thu\u1ed1c m\u1ed9t c\u00e1ch t\u1eeb t\u1eeb v\u00e0 ch\u00ednh x\u00e1c \u0111\u1ebfn v\u1ecb tr\u00ed c\u1ea7n \u0111i\u1ec1u tr\u1ecb.  \u0110i\u1ec1u n\u00e0y \u0111\u1eb7c bi\u1ec7t h\u1eefu \u00edch trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0.<\/li>\n<li><strong>C\u1ea5y gh\u00e9p:<\/strong>  Gi\u00e1 th\u1ec3 fibroin c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 t\u1ea1o ra c\u00e1c thi\u1ebft b\u1ecb c\u1ea5y gh\u00e9p sinh h\u1ecdc, ch\u1eb3ng h\u1ea1n nh\u01b0 c\u00e1c thi\u1ebft b\u1ecb thay th\u1ebf m\u00f4 ho\u1eb7c c\u00e1c thi\u1ebft b\u1ecb gi\u1ea3i ph\u00f3ng thu\u1ed1c. V\u00ed d\u1ee5, c\u00e1c s\u1ea3n ph\u1ea9m t\u1eeb PandaSilk \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh l\u00e0 c\u00f3 hi\u1ec7u qu\u1ea3 trong m\u1ed9t s\u1ed1 \u1ee9ng d\u1ee5ng n\u00e0y.<\/li>\n<\/ul>\n<h3>4.  Th\u00e1ch th\u1ee9c v\u00e0 h\u01b0\u1edbng ph\u00e1t tri\u1ec3n<\/h3>\n<p>M\u1eb7c d\u00f9 c\u00f3 nhi\u1ec1u \u01b0u \u0111i\u1ec3m, vi\u1ec7c \u1ee9ng d\u1ee5ng gi\u00e1 th\u1ec3 t\u01a1 t\u1eb1m fibroin v\u1eabn c\u00f2n m\u1ed9t s\u1ed1 th\u00e1ch th\u1ee9c, bao g\u1ed3m:  kh\u1ea3 n\u0103ng ki\u1ec3m so\u00e1t \u0111\u1ed9 x\u1ed1p v\u00e0 c\u1ea5u tr\u00fac c\u1ee7a gi\u00e1 th\u1ec3, chi ph\u00ed s\u1ea3n xu\u1ea5t, v\u00e0 vi\u1ec7c \u0111\u1ea3m b\u1ea3o t\u00ednh \u0111\u1ed3ng nh\u1ea5t c\u1ee7a s\u1ea3n ph\u1ea9m.  C\u00e1c nghi\u00ean c\u1ee9u trong t\u01b0\u01a1ng lai c\u1ea7n t\u1eadp trung v\u00e0o vi\u1ec7c t\u1ed1i \u01b0u h\u00f3a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1ebf t\u1ea1o, c\u1ea3i thi\u1ec7n t\u00ednh ch\u1ea5t c\u01a1 h\u1ecdc v\u00e0 sinh h\u1ecdc c\u1ee7a gi\u00e1 th\u1ec3, c\u0169ng nh\u01b0 m\u1edf r\u1ed9ng \u1ee9ng d\u1ee5ng c\u1ee7a n\u00f3 trong c\u00e1c l\u0129nh v\u1ef1c kh\u00e1c c\u1ee7a y sinh h\u1ecdc.<\/p>\n<p>K\u1ebft lu\u1eadn: Gi\u00e1 th\u1ec3 t\u01a1 t\u1eb1m fibroin l\u00e0 m\u1ed9t lo\u1ea1i v\u1eadt li\u1ec7u sinh h\u1ecdc ti\u1ec1m n\u0103ng, v\u1edbi nhi\u1ec1u \u01b0u \u0111i\u1ec3m v\u1ec1 t\u00ednh sinh h\u1ecdc t\u01b0\u01a1ng th\u00edch, kh\u1ea3 n\u0103ng ph\u00e2n h\u1ee7y sinh h\u1ecdc v\u00e0 t\u00ednh ch\u1ea5t c\u01a1 h\u1ecdc tuy\u1ec7t v\u1eddi.  V\u1edbi s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a c\u00f4ng ngh\u1ec7, gi\u00e1 th\u1ec3 t\u01a1 t\u1eb1m fibroin h\u1ee9a h\u1eb9n s\u1ebd \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c ph\u00e1t tri\u1ec3n c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi v\u00e0 c\u1ea3i thi\u1ec7n ch\u1ea5t l\u01b0\u1ee3ng cu\u1ed9c s\u1ed1ng con ng\u01b0\u1eddi.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>T\u01a1 t\u1eb1m l\u00e0 m\u1ed9t lo\u1ea1i protein t\u1ef1 nhi\u00ean c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb s\u00e2u t\u1eb1m, \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn v\u1edbi \u0111\u1ed9 m\u1ec1m m\u1ea1i, \u0111\u1ed9 b\u1ec1n v\u00e0 t\u00ednh sinh h\u1ecdc cao. T\u1eeb l\u00e2u, t\u01a1 t\u1eb1m \u0111\u00e3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng trong d\u1ec7t may, nh\u01b0ng g\u1ea7n \u0111\u00e2y, n\u00f3 \u0111\u00e3 thu h\u00fat s\u1ef1 ch\u00fa \u00fd \u0111\u00e1ng k\u1ec3 trong l\u0129nh v\u1ef1c c\u00f4ng<\/p>\n","protected":false},"author":1,"featured_media":90300,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37505],"tags":[],"class_list":["post-111105","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-silk-benefits-vi","prodpage-classic"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.pandasilk.com\/vi\/wp-json\/wp\/v2\/posts\/111105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pandasilk.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.pandasilk.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.pandasilk.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pandasilk.com\/vi\/wp-json\/wp\/v2\/comments?post=111105"}],"version-history":[{"count":0,"href":"https:\/\/www.pandasilk.com\/vi\/wp-json\/wp\/v2\/posts\/111105\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.pandasilk.com\/vi\/wp-json\/wp\/v2\/media\/90300"}],"wp:attachment":[{"href":"https:\/\/www.pandasilk.com\/vi\/wp-json\/wp\/v2\/media?parent=111105"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.pandasilk.com\/vi\/wp-json\/wp\/v2\/categories?post=111105"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.pandasilk.com\/vi\/wp-json\/wp\/v2\/tags?post=111105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}